Collaborative Research Center (Transregio 241)

TRR 241 – Research for a Better Understanding of IBD

Inflammatory bowel diseases (IBD), such as Crohn’s disease and ulcerative colitis, affect millions of people worldwide. Despite intensive research efforts, the exact causes of these chronic conditions remain incompletely understood. The Collaborative Research Center Transregio 241 (TRR 241) investigates the complex communication between the immune system and the intestinal barrier to gain new insights into the development, progression, and treatment of IBD.

TRR 241 is a leading research consortium funded by the German Research Foundation (DFG). With sites in Erlangen, Berlin, and Kiel, it brings together Germany’s top IBD treatment centers and distinguished experts in gastroenterology, immunology, and molecular and cellular biology.

These specialists contribute their expertise in experimental, translational, and clinical research to uncover the cellular and molecular mechanisms driving IBD. Our goal: to not only better understand IBD, but to develop targeted therapies that improve treatment and enhance the quality of life for patients.

The scientific concept of TRR 241 focuses on the intestinal barrier as a communication interface between the microbiota and the immune system. We study how this dialogue is disrupted in IBD and aim to identify faulty mechanisms. Ultimately, we seek to develop strategies that can specifically modulate these pathways and restore intestinal health.

Project Area

A

focuses on the immune regulation of intestinal barrier functions, including the effects of chronic and acute inflammation on epithelial cells — particularly with regard to cell homeostasis, differentiation, and barrier formation.

Project Area

B

investigates the role of the intestinal epithelium as a regulator of immunity and inflammation, including the impact of barrier defects and antigen translocation on the mucosal immune system.

Project Area

C

focuses on the development and evaluation of innovative diagnostic and therapeutic strategies to improve the treatment of IBD.

Project Area

Z

supports TRR241 through central coordination, early-career training, equal opportunity measures, and data infrastructure. It contributes to the strategic development of the consortium, fosters scientific excellence, and facilitates cross-site collaboration.