A phase II multi-center clinical trial to study the efficacy and in vivo trafficking of autologous adoptively transferred ex vivo expanded regulatory T cells in patients with ulcerative colitis
Project Summary
Adoptive transfer of regulatory T cells (Tregs) has been successfully employed to block experimental colitis in vivo; however, their use for treating patients with ulcerative colitis (UC) remains poorly explored. The homing of these Tregs to the gut and their effects on the intestinal epithelium are crucial for suppressing gut-specific inflammation. In this project, we aim to further delineate the molecular mechanisms governing mucosal trafficking and retention of Tregs in ulcerative colitis. We will combine the clinical evaluation of our current GMP-approved Treg product in a Phase II clinical trial with in-depth studies on their gut functionality. These investigations will inform future efforts to refine and optimize the existing GMP-grade Treg therapy.
Selected project-relevant publications
Trajanoski Z, Plattner C, Sturm G, Kühl A, Atreya R, Carollo S, Gronauer R, Rieder D, Günther M, Ormanns S, Manzl C, Wirtz S, Meneghetti A, Hegazy A, Patankar J, Carrero Z, Neurath M, Kather J, Becker C, Siegmund B.
IBDome: An integrated molecular, histopathological, and clinical atlas of inflammatory bowel diseases.
Res Sq [Preprint]. 2025 May 6:rs.3.rs-6443303. doi: 10.21203/rs.3.rs-6443303/v1. PMID: 40386420; PMCID: PMC12083645.
Plechschmidt J, Fietkau K, Hepp T, Dietrich P, Fischer S, Krebs S, Neurath MF, Dörje F, Atreya R.
Clinical Pharmacist Counselling Improves Long-term Medication Safety and Patient-reported Outcomes in Anti-TNF-treated Patients With Inflammatory Bowel Diseases: The Prospective, Randomized AdPhaNCED Trial.
Inflamm Bowel Dis. 2025 Jan 6;31(1):77-86. doi: 10.1093/ibd/izae040.
Bao LL, Yu YQ, González-Acera M, Patankar JV, Giessl A, Sturm G, Kühl AA, Atreya R, Erkert L, Gámez-Belmonte R, Krug SM, Schmid B, Tripal P, Chiriac MT, Hildner K, Siegmund B, Wirtz S, Stürzl M, Mohamed Abdou M, Trajanoski Z; TRR241 IBDome Consortium; Neurath MF, Zorzano A, Becker C.
Epithelial OPA1 links mitochondrial fusion to inflammatory bowel disease.
Sci Transl Med. 2025 Jan 15;17(781):eadn8699. doi: 10.1126/scitranslmed.adn8699.
Müller TM, Liu LJ, Wiesinger M; TRR241 IBDome Consortium; Neurath MF, Voskens CJ, Zundler S.
Engineering Therapeutic Regulatory T Cells to Overexpress G Protein-Coupled Receptor 15 Improves Functional Fitness for In Vivo Gut Homing.
Gastroenterology. 2025 Feb;168(2):389-392.e4. doi: 10.1053/j.gastro.2024.10.003.
Roth D, Düll MM, Horst LJ, Lindemann A, Malzer X, Koop K, Zundler S, Vetter M, Jefremow A, Atreya R, Geppert C, Weidemann S, Waldner MJ, Dietrich P, Günther C, Munoz LE, Herrmann M, Scheffold A, Neurath MF, Siebler J, Schramm C, Kremer AE, Leppkes M.
Integrin αVβ6: Autoantigen and Driver of Epithelial Remodeling in Colon and Bile Ducts in Primary Sclerosing Cholangitis and Inflammatory Bowel Disease.
J Crohns Colitis. 2025 Feb 4;19(2):jjae131. doi: 10.1093/ecco-jcc/jjae131.
Beck M, Kuwert T, Atzinger A, Gerner M, Hartmann A, Saake M, Uder M, Neurath MF, Atreya R.
Discrimination between Inflammatory and Fibrotic Activity in Crohn’s Disease-Associated Ileal-Colonic Anastomotic Strictures by Combined Ga-68-FAPI-46 and F-18-FDG-PET/CT Imaging.
Visc Med. 2025 Feb;41(1):1-13. doi: 10.1159/000542160.
Gonzalez-Acera M, Patankar JV, Erkert L, Cineus R, Gamez-Belmonte R, Leupold T, Bubeck M, Bao LL, Dinkel M, Wang R, Schickedanz L, Limberger H, Stolzer I, Gerlach K, Diemand L, Mascia F, Gupta P, Naschberger E, Koop K, Plattner C, Sturm G, Weigmann B, Günther C, Wirtz S, Stürzl M, Hildner K, Kühl AA, Siegmund B, Gießl A, Atreya R; TRR241 IBDome Consortium; Hegazy AN, Trajanoski Z, Neurath MF, Becker C.
Integrated multimodel analysis of intestinal inflammation exposes key molecular features of preclinical and clinical IBD.
Gut. 2025 Apr 29:gutjnl-2024-333729. doi: 10.1136/gutjnl-2024-333729.
Plattner C, Sturm G, Kühl AA, Atreya R, Carollo S, Gronauer R, Rieder D, Günther M, Ormanns S, Manzl C, Wirtz S, Meneghetti AR, Hegazy AN, Patankar JV, Carrero ZI; TRR241 IBDome Consortium; Neurath MF, Kather JN, Becker C, Siegmund B, Trajanoski Z.
IBDome: An integrated molecular, histopathological, and clinical atlas of inflammatory bowel diseases.
bioRxiv [Preprint]. 2025 Apr 10:2025.03.26.645544. doi: 10.1101/2025.03.26.645544.
Erkert L, Ruder B, Kabisch M, Gamez Belmonte R, Patankar JV, Gonzalez Acera M, Schödel L, Chiriac MT, Cineus R, Gnafakis S, Leupold T, Thoma OM, Stolzer I, Taut A, Thonn V, Zundler S, Günther C, Diefenbach A, Kühl AA, Hegazy AN, Waldner M, Basic M, Bleich A, Neurath MF, Wirtz S, Becker C; TRR241 IBDome Consortium.
TIFA renders intestinal epithelial cells responsive to microbial ADP-heptose and drives colonic inflammation in mice.
Mucosal Immunol. 2025 Apr;18(2):453-466. doi: 10.1016/j.mucimm.2025.01.003.
Erkert L, Kabisch M, Gamez-Belmonte R, Gonzalez-Acera M, Patankar JV, Schödel L, Hofmann K, Wagner Y, Plattner C, Spath EM, Distler U, Tenzer S; TRR241 IBDome Consortium; Neufert C, Neurath MF, Becker C.
Pharmacological inhibitors of the gamma-secretase enzyme complex disrupt epithelial cell function triggering colitis in mice.
J Crohns Colitis. 2025 Jun 12:jjaf096. doi: 10.1093/ecco-jcc/jjaf096.
Wagner K, Müller TM, Vitali F, Fischer S, Haberkamp S, Rouse-Merkel R, Atreya R, Neurath MF, Zundler S.
Treatment trajectories and outcomes in inflammatory bowel disease: a tertiary single-centre experience.
Therap Adv Gastroenterol. 2024 Sep 28;17:17562848241284051. doi: 10.1177/17562848241284051. PMID: 39381754; PMCID: PMC11459667.
Dorner H, Stolzer I, Mattner J, Kaminski S, Leistl S, Edrich LM, Schwendner R, Hobauer J, Sebald A, Leikam S, Gonzalez Acera M, Düll M, Lang R, Seidel G, Seitz T, Hellerbrand C, Fuhrmann G, Distler U, Tenzer S, Eichhorn P, Vieth M, Schramm C, Arnold P, Becker C, Weidinger C, Siegmund B, Atreya R, Leppkes M, Naschberger E, Sampaziotis F, Dietrich P, Rauh M, Wirtz S, Kremer AE, Neurath MF, Günther C.
Gut Pathobiont-Derived Outer Membrane Vesicles Drive Liver Inflammation and Fibrosis in Primary Sclerosing Cholangitis-Associated Inflammatory Bowel Disease.
Gastroenterology. 2024 Nov;167(6):1183-1197.e16. doi: 10.1053/j.gastro.2024.06.032. Epub 2024 Jul 9. PMID: 38992449.
Plechschmidt J, Fietkau K, Hepp T, Dietrich P, Fischer S, Krebs S, Neurath MF, Dörje F, Atreya R.
Clinical Pharmacist Counselling Improves Long-term Medication Safety and Patient-reported Outcomes in Anti-TNF-treated Patients With Inflammatory Bowel Diseases: The Prospective, Randomized AdPhaNCED Trial.
Inflamm Bowel Dis. 2025 Jan 6;31(1):77-86. doi: 10.1093/ibd/izae040. PMID: 38507608; PMCID: PMC11700895.
Weber S, Sitte S, Voegele AL, Sologub L, Wilfer A, Rath T, Nägel A, Zundler S, Franchi L, Opipari AW, Sonnewald S, Reid S, Hartmann A, Eichhorn P, Handtrack C, Weber K, Grützmann R, Neufert C, Schellerer VS, Naschberger E, Ekici AB, Büttner C, Neurath MF, Atreya R.
NLRP3 Inhibition Leads to Impaired Mucosal Fibroblast Function in Patients with Inflammatory Bowel Diseases.
J Crohns Colitis. 2024 Mar 1;18(3):446-461. doi: 10.1093/ecco-jcc/jjad164. PMID: 37748021.
Thoma OM, Naschberger E, Kubánková M, Larafa I, Kramer V, Menchicchi B, Merkel S, Britzen-Laurent N, Jefremow A, Grützmann R, Koop K, Neufert C, Atreya R, Guck J, Stürzl M, Neurath MF, Waldner MJ.
p21 Prevents the Exhaustion of CD4+ T Cells Within the Antitumor Immune Response Against Colorectal Cancer.
Gastroenterology. 2024 Feb;166(2):284-297.e11. doi: 10.1053/j.gastro.2023.09.017. Epub 2023 Sep 19. PMID: 37734420.
Chiriac MT, Hracsko Z, Günther C, Gonzalez-Acera M, Atreya R, Stolzer I, Wittner L, Dressel A, Schickedanz L, Gamez-Belmonte R, Erkert L, Hundorfean G, Zundler S, Rath T, Vetrano S, Danese S, Sturm G, Trajanoski Z, Kühl AA, Siegmund B, Hartmann A, Wirtz S, Siebler J, Finotto S, Becker C, Neurath MF.
IL-20 controls resolution of experimental colitis by regulating epithelial IFN/STAT2 signalling.
Gut. 2024 Jan 5;73(2):282-297. doi: 10.1136/gutjnl-2023-329628. PMID: 37884352; PMCID: PMC10850655.
Fischer S, Donhauser M, Cohnen S, Fietkau K, Vetter M, Grübel-Liehr M, Dietrich P, Rath T, Wilfer A, Sologub L, Krebs S, Dörje F, Nagore D, Meyer S, Neurath MF, Atreya R.
Reverse switching from the biosimilar SB2 to the originator infliximab in previously switched patients with inflammatory bowel diseases: results of a prospective long-term cohort study.
Therap Adv Gastroenterol. 2024 Nov 30;17:17562848241301887. doi: 10.1177/17562848241301887. PMID: 39619829; PMCID: PMC11608450.
Beck M, Kuwert T, Atzinger A, Gerner M, Hartmann A, Saake M, Uder M, Neurath MF, Atreya R.
Discrimination between Inflammatory and Fibrotic Activity in Crohn’s Disease-Associated Ileal-Colonic Anastomotic Strictures by Combined Ga-68-FAPI-46 and F-18-FDG-PET/CT Imaging.
Visc Med. 2025 Feb;41(1):1-13. doi: 10.1159/000542160. Epub 2024 Dec 20. PMID: 39927190; PMCID: PMC11801851.
Müller TM, Liu LJ, Wiesinger M; TRR241 IBDome Consortium; Neurath MF, Voskens CJ, Zundler S.
Engineering Therapeutic Regulatory T Cells to Overexpress G Protein-Coupled Receptor 15 Improves Functional Fitness for In Vivo Gut Homing.
Gastroenterology. 2025 Feb;168(2):389-392.e4. doi: 10.1053/j.gastro.2024.10.003. Epub 2024 Oct 9. PMID: 39389186.
Gámez-Belmonte R, Wagner Y, Mahapatro M, Wang R, Erkert L, González-Acera M, Cineus R, Hainbuch S, Patankar JV, Voehringer D, Hegazy AN, Neurath MF, Wirtz S, Becker C.
Intestinal epithelial Gasdermin C is induced by IL-4R/STAT6 signaling but is dispensable for gut immune homeostasis.
Sci Rep. 2024 Nov 3;14(1):26522. doi: 10.1038/s41598-024-78336-z. PMID: 39489845; PMCID: PMC11532336.
Wiendl M, Dedden M, Liu LJ, Schweda A, Paap EM, Ullrich KA, Hartmann L, Wieser L, Vitali F, Atreya I, Müller TM, Günther C, Atreya R, Neurath MF, Zundler S.
Etrolizumab-s fails to control E-Cadherin-dependent co-stimulation of highly activated cytotoxic T cells.
Nat Commun. 2024 Feb 3;15(1):1043. doi: 10.1038/s41467-024-45352-6. PMID: 38310086; PMCID: PMC10838339.
Erkert L, Gamez-Belmonte R, Kabisch M, Schödel L, Patankar JV, Gonzalez-Acera M, Mahapatro M, Bao LL, Plattner C, Kühl AA, Shen J, Serneels L, De Strooper B; TRR241 IBDome Consortium; Neurath MF, Wirtz S, Becker C.
Alzheimer’s disease-related presenilins are key to intestinal epithelial cell function and gut immune homoeostasis.
Gut. 2024 Sep 9;73(10):1618-1631. doi: 10.1136/gutjnl-2023-331622. PMID: 38684238.
Schulz-Kuhnt A, Rühle K, Javidmehr A, Döbrönti M, Biwank J, Knittel S, Neidlinger P, Leupold J, Liu LJ, Dedden M, Taudte RV, Gessner A, Fromm MF, Mielenz D, Kreiss L, Waldner MJ, Schürmann S, Friedrich O, Dietel B, López-Posadas R, Plattner C; TRR241 IBDome Consortium; Zundler S, Becker C, Atreya R, Neurath MF, Atreya I.
ATP citrate lyase (ACLY)-dependent immunometabolism in mucosal T cells drives experimental colitis in vivo.
Gut. 2024 Mar 7;73(4):601-612. doi: 10.1136/gutjnl-2023-330543. PMID: 38176897.
Sommer K, Heidbreder K, Kreiss L, Dedden M, Paap EM, Wiendl M, Becker E, Atreya R, Müller TM, Atreya I, Waldner M, Schürmann S, Friedrich O, Neurath MF, Zundler S.
Anti-β7 integrin treatment impedes the recruitment on non-classical monocytes to the gut and delays macrophage-mediated intestinal wound healing.
Clin Transl Med. 2023 Apr;13(4):e1233. doi: 10.1002/ctm2.1233. PMID: 37029786; PMCID: PMC10082567.
Ullrich KA, Derdau J, Baltes C, Battistella A, Rosso G, Uderhardt S, Schulze LL, Liu LJ, Dedden M, Spocinska M, Kainka L, Kubánková M, Müller TM, Schmidt NM, Becker E, Ben Brahim O, Atreya I, Finotto S, Prots I, Wirtz S, Weigmann B, López-Posadas R, Atreya R, Ekici AB, Lautenschläger F, Guck J, Neurath MF, Zundler S.
IL-3 receptor signalling suppresses chronic intestinal inflammation by controlling mechanobiology and tissue egress of regulatory T cells.
Gut. 2023 Nov;72(11):2081-2094. doi: 10.1136/gutjnl-2023-329818. Epub 2023 Aug 4. PMID: 37541770; PMCID: PMC10579496.
Gamez-Belmonte R, Mahapatro M, Erkert L, Gonzalez-Acera M, Naschberger E, Yu Y, Tena-Garitaonaindia M, Patankar JV, Wagner Y, Podstawa E, Schödel L, Bubeck M, Neurath MF, Stürzl M, Becker C.
Epithelial presenilin-1 drives colorectal tumour growth by controlling EGFR-COX2 signalling.
Gut. 2023 Jun;72(6):1155-1166. doi: 10.1136/gutjnl-2022-327323. Epub 2022 Oct 19. PMID: 36261293.
Müller TM, Liu LJ, Czerwinski T, Wiesinger M, Dedden M, Paap EM, Ullrich KA, Atreya I, Siegmund B, Atreya R, Fabry B, Berking C, Neurath MF, Zundler S, Voskens CJ.
Increased Motility and Suppression of Ex Vivo-Expanded Regulatory T Cells Designed for Adoptive Transfer Therapy in Ulcerative Colitis.
Cell Mol Gastroenterol Hepatol. 2023;16(1):183-187.e2. doi: 10.1016/j.jcmgh.2023.04.002. Epub 2023 Apr 20. Erratum in: Cell Mol Gastroenterol Hepatol. 2025 Jun 6:101554. doi: 10.1016/j.jcmgh.2025.101554. PMID: 37085136; PMCID: PMC10285232.
Wittner L, Wagener L, Wiese JJ, Stolzer I, Krug SM, Naschberger E, Jackstadt R, Beyaert R, Atreya R, Kühl AA, Sturm G, Gonzalez-Acera M, Patankar JV, Becker C, Siegmund B, Trajanoski Z, Winner B, Neurath MF, Schumann M, Günther C.
Proteolytic Activity of the Paracaspase MALT1 Is Involved in Epithelial Restitution and Mucosal Healing.
Int J Mol Sci. 2023 Apr 17;24(8):7402. doi: 10.3390/ijms24087402. PMID: 37108564; PMCID: PMC10138456.
Schneider I, Allner C, Mühl L, Melde M, Lissner D, Mantzivi E, Glauben R, Vitali F, Becker E, Atreya I, Müller TM, Atreya R, Siegmund B, Neurath MF, Zundler S.
Expression and function of α4β7 integrin predict the success of vedolizumab treatment in inflammatory bowel disease.
Transl Res. 2023 Mar;253:8-15. doi: 10.1016/j.trsl.2022.10.003. Epub 2022 Oct 20. PMID: 36272713.
Martínez-Sánchez LDC, Ngo PA, Pradhan R, Becker LS, Boehringer D, Soteriou D, Kubankova M, Schweitzer C, Koch T, Thonn V, Erkert L, Stolzer I, Günther C, Becker C, Weigmann B, Klewer M, Daniel C, Amann K, Tenzer S, Atreya R, Bergo M, Brakebusch C, Watson AJM, Guck J, Fabry B, Atreya I, Neurath MF, López-Posadas R.
Epithelial RAC1-dependent cytoskeleton dynamics controls cell mechanics, cell shedding and barrier integrity in intestinal inflammation.
Gut. 2023 Feb;72(2):275-294. doi: 10.1136/gutjnl-2021-325520. Epub 2022 Mar 3. PMID: 35241625; PMCID: PMC9872254.
Rath T, Atreya R, Bodenschatz J, Uter W, Geppert CE, Vitali F, Fischer S, Waldner MJ, Colombel JF, Hartmann A, Neurath MF.
Intestinal Barrier Healing Is Superior to Endoscopic and Histologic Remission for Predicting Major Adverse Outcomes in Inflammatory Bowel Disease: The Prospective ERIca Trial.
Gastroenterology. 2023 Feb;164(2):241-255. doi: 10.1053/j.gastro.2022.10.014. Epub 2022 Oct 21. PMID: 36279923.
Heidbreder K, Sommer K, Wiendl M, Müller TM, Atreya I, Hildner K, Neurath MF, Zundler S.
Nr4a1-dependent non-classical monocytes are important for macrophage-mediated wound healing in the large intestine.
Front Immunol. 2023 Jan 18;13:1040775. doi: 10.3389/fimmu.2022.1040775. PMID: 36741412; PMCID: PMC9890957.
Voskens C, Stoica D, Rosenberg M, Vitali F, Zundler S, Ganslmayer M, Knott H, Wiesinger M, Wunder J, Kummer M, Siegmund B, Schnoy E, Rath T, Hartmann A, Hackstein H, Schuler-Thurner B, Berking C, Schuler G, Atreya R, Neurath MF.
Autologous regulatory T-cell transfer in refractory ulcerative colitis with concomitant primary sclerosing cholangitis.
Gut. 2023 Jan;72(1):49-53. doi: 10.1136/gutjnl-2022-327075. Epub 2022 Apr 15. PMID: 35428657; PMCID: PMC9763232.
Schulze LL, Becker E, Dedden M, Liu LJ, van Passen C, Mohamed-Abdou M, Müller TM, Wiendl M, Ullrich KAM, Atreya I, Leppkes M, Ekici AB, Kirchner P, Stürzl M, Sexton D, Palliser D, Atreya R, Siegmund B; TRR241 IBDome consortium; Neurath MF, Zundler S.
Differential Effects of Ontamalimab Versus Vedolizumab on Immune Cell Trafficking in Intestinal Inflammation and Inflammatory Bowel Disease.
J Crohns Colitis. 2023 Nov 24;17(11):1817-1832. doi: 10.1093/ecco-jcc/jjad088. PMID: 37208197.
Koop K, Enderle K, Hillmann M, Ruspeckhofer L, Vieth M, Sturm G, Trajanoski Z, Kühl AA, Atreya R, Leppkes M, Baum P, Roy J, Martin A, Neurath MF, Neufert C.
Interleukin 36 receptor-inducible matrix metalloproteinase 13 mediates intestinal fibrosis.
Front Immunol. 2023 May 3;14:1163198. doi: 10.3389/fimmu.2023.1163198. PMID: 37207229; PMCID: PMC10189878.
Soteriou D, Kubánková M, Schweitzer C, López-Posadas R, Pradhan R, Thoma OM, Györfi AH, Matei AE, Waldner M, Distler JHW, Scheuermann S, Langejürgen J, Eckstein M, Schneider-Stock R, Atreya R, Neurath MF, Hartmann A, Guck J.
Rapid single-cell physical phenotyping of mechanically dissociated tissue biopsies.
Nat Biomed Eng. 2023 Nov;7(11):1392-1403. doi: 10.1038/s41551-023-01015-3. Epub 2023 Apr 6. PMID: 37024677; PMCID: PMC10651479.
Gerlach K, Popp V, Wirtz S, Al-Saifi R, Gonzalez Acera M, Atreya R, Dregelies T, Vieth M, Fichtner-Feigl S, McKenzie ANJ, Rosenbauer F, Weigmann B, Neurath MF.
PU.1-driven Th9 Cells Promote Colorectal Cancer in Experimental Colitis Models Through Il-6 Effects in Intestinal Epithelial Cells.
J Crohns Colitis. 2022 Dec 5;16(12):1893-1910. doi: 10.1093/ecco-jcc/jjac097. PMID: 35793807; PMCID: PMC10197880.
Kreiss L, Thoma OM, Lemire S, Lechner K, Carlé B, Dilipkumar A, Kunert T, Scheibe K, Heichler C, Merten AL, Weigmann B, Neufert C, Hildner K, Vieth M, Neurath MF, Friedrich O, Schürmann S, Waldner MJ.
Label-Free Characterization and Quantification of Mucosal Inflammation in Common Murine Colitis Models With Multiphoton Imaging.
Inflamm Bowel Dis. 2022 Nov 2;28(11):1637-1646. doi: 10.1093/ibd/izac114. PMID: 35699622; PMCID: PMC9629455.
Schmalzl A, Leupold T, Kreiss L, Waldner M, Schürmann S, Neurath MF, Becker C, Wirtz S.
Interferon regulatory factor 1 (IRF-1) promotes intestinal group 3 innate lymphoid responses during Citrobacter rodentium infection.
Nat Commun. 2022 Sep 29;13(1):5730. doi: 10.1038/s41467-022-33326-5. PMID: 36175404; PMCID: PMC9522774.
Besendorf L, Müller TM, Geppert CI, Schneider I, Mühl L, Atreya I, Vitali F, Atreya R, Neurath MF, Zundler S.
Vedolizumab blocks α4β7 integrin-mediated T cell adhesion to MAdCAM-1 in microscopic colitis.
Therap Adv Gastroenterol. 2022 Jun 28;15:17562848221098899. doi: 10.1177/17562848221098899. PMID: 35784193; PMCID: PMC9244938.
Lemire S, Thoma OM, Kreiss L, Völkl S, Friedrich O, Neurath MF, Schürmann S, Waldner MJ.
Natural NADH and FAD Autofluorescence as Label-Free Biomarkers for Discriminating Subtypes and Functional States of Immune Cells.
Int J Mol Sci. 2022 Feb 20;23(4):2338. doi: 10.3390/ijms23042338. PMID: 35216453; PMCID: PMC8880312.
Buchbender M, Fehlhofer J, Proff P, Möst T, Ries J, Hannig M, Neurath MF, Gund M, Atreya R, Kesting M.
Expression of inflammatory mediators in biofilm samples and clinical association in inflammatory bowel disease patients-a preliminary study.
Clin Oral Investig. 2022 Feb;26(2):1217-1228. doi: 10.1007/s00784-021-04093-2. Epub 2021 Aug 12. PMID: 34383142; PMCID: PMC8816497.
Kreiss L, Ganzleben I, Mühlberg A, Ritter P, Schneidereit D, Becker C, Neurath MF, Friedrich O, Schürmann S, Waldner M.
Label-free analysis of inflammatory tissue remodeling in murine lung tissue based on multiphoton microscopy, Raman spectroscopy and machine learning.
J Biophotonics. 2022 Sep;15(9):e202200073. doi: 10.1002/jbio.202200073. Epub 2022 Jun 26. PMID: 35611635.
Yu YQ, Thonn V, Patankar JV, Thoma OM, Waldner M, Zielinska M, Bao LL, Gonzalez-Acera M, Wallmüller S, Engel FB, Stürzl M, Neurath MF, Liebing E, Becker C.
SMYD2 targets RIPK1 and restricts TNF-induced apoptosis and necroptosis to support colon tumor growth.
Cell Death Dis. 2022 Jan 12;13(1):52. doi: 10.1038/s41419-021-04483-0. PMID: 35022391; PMCID: PMC8755774.