2020
INFLAMMATORY BOWEL DISEASES
Volume: 26
Published: January 2020
DOI: 10.1093/ibd/izz142
Environmental Microbial Factors Determine the Pattern of Inflammatory Lesions in a Murine Model of Crohn’s Disease–Like Inflammation
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
Volume: 17
Published: January 2020
DOI: 10.1038/s41575-019-0228-5
Jonathan L. Digby-Bell, Raja Atreya, Giovanni Monteleone, Nick Powell
Interrogating host immunity to predict treatment response in inflammatory bowel disease
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume:
Published: February 2020
DOI: 10.1002/eji.201948474
Specific microbiota enhances intestinal IgA levels by inducing TGF-β in T follicular helper cells of Peyer’s patches in mice.
FRONTIERS IN IMMUNOLOGY
Volume: 11
Published: February 2020
DOI: 10.3389/fimmu.2020.00209
Markus Kindermann, Lisa Knipfer, Stephanie Obermeyer, Uwe Müller, Gottfried Alber, Christian Bogdan, Ulrike Schleicher, Markus F. Neurath, Stefan Wirtz
Group 2 Innate Lymphoid Cells (ILC2) Suppress Beneficial Type 1 Immune Responses During Pulmonary Cryptococcosis.
CANCERS
Volume: 12
Published: February 2020
DOI: 10.3390/cancers12020488
Grazia Carbotti, Andrea Petretto, Elisabeth Naschberger, Michael Stürzl, Stefania Martini, Maria Cristina Mingari, Gilberto Filaci, Silvano Ferrini, Marina Fabbi
Cytokine-Induced Guanylate Binding Protein 1 (GBP1) Release from Human Ovarian Cancer Cells
JOURNAL OF MOLECULAR BIOLOGY
Volume: 432
Published: March 2020
DOI: 10.1016/j.jmb.2020.02.009
Linda Sistemich, Miriam Kutsch, Benjamin Hämisch, Ping Zhang, Sergii Shydlovskyi, Nathalie Britzen-Laurent, Michael Stürzl, Klaus Huber, Christian Herrmann
The Molecular Mechanism of Polymer Formation of Farnesylated Human Guanylate-binding Protein 1
IMMUNITY
Volume: 52
Published: March 2020
DOI: 10.1016/j.immuni.2020.02.016
Andreas Diefenbach, Stylianos Gnafakis, Omer Shomrat
Innate Lymphoid Cell-Epithelial Cell Modules Sustain Intestinal Homeostasis
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
Volume: –
Published: March 2020
DOI: 10.3791/60546
Marco Bardenbacher, Barbara Ruder, Nathalie Britzen-Laurent, Elisabeth Naschberger, Christoph Becker, Ralph Palmisano, Michael Stürzl, Philipp Tripal
Investigating Intestinal Barrier Breakdown in Living Organoids
NATURE REVIEWS IMMUNOLOGY
Volume: 20
Published: April 2020
DOI: 10.1038/s41577-020-0312-7
Georg Schett, Michael Sticherling, Markus F. Neurath
COVID-19: risk for cytokine targeting in chronic inflammatory diseases?
AMERICAN JOURNAL OF GASTROENTEROLOGY
Volume: 115
Published: April 2020
DOI: 10.14309/ajg.0000000000000571
Ingo Ganzleben, Simon Hirschmann, Julia Kohler, Florian S. Fuchs, Ralf J. Rieker, Eva Baer, Entcho Klenske, Daniel Nagore, Markus F. Neurath, Raja Atreya
Successful Therapy of Crohn´s Disease-Associated Pulmonary Necrobiotic Nodules on Ustekinumab Therapy
NATURE COMMUNICATIONS
Volume: 11
Published: April 2020
DOI: 10.1038/s41467-020-15646-6
Lisa Mayr, Felix Grabherr, Julian Schwrzler, Isabelle Reitmeier, Felix Sommer, Thomas Gehmacher, Lukas Niederreiter, Gui-Wei He, Barbara Ruder, Kai T. R. Kunz, Piotr Tymoszuk, Richard Hilbe, David Haschka, Clemens Feistritzer, Romana R. Gerner, Barbara Enrich, Nicole Przysiecki, Markus Seifert, Markus A. Keller, Georg Oberhuber, Susanne Sprung, Qitao Ran, Robert Koch, Maria Effenberger, Ivan Tancevski, Heinz Zoller, Alexander R. Moschen, Gnter Weiss, Christoph Becker, Philip Rosenstiel, Arthur Kaser, Herbert Tilg, Timon E. Adolph
Dietary lipids fuel GPX4-restricted enteritis resembling Crohn´s disease
VISCERAL MEDICINE
Volume: 36
Published: April 2020
DOI: 10.1159/000506846
Sebastian Zundler, Verena Tauschek, Markus F. Neurath
Immune Cell Circuits in Mucosal Wound Healing: Clinical Implications
PLOS ONE
Volume: 15
Published: May 2020
DOI: 10.1371/journal.pone.0233422
Anika Klingler, Daniela Regensburger, Clara Tenkerian, Nathalie Britzen-Laurent, Arndt Hartmann, Michael Stürzl, Elisabeth Naschberger
Species-, organ– and cell-type-dependent expression of SPARCL1 in human and mouse tissues
CROHN´S & COLITIS 360
Volume: 2
Published: April 2020
DOI: 10.1093/crocol/otaa037
Matthias Breidert, Pierre Eftekhari, Francois Louis, Claudia Rotoiu, Timo Rath, Markus F. Neurath, Raja Atreya
Functional Molecular Network Analysis Enables Prediction of Response to Vedolizumab Therapy in Anti-TNF Refractory IBD Patients
SCIENTIFIC REPORTS
Volume: 10
Published: May 2020
DOI: 10.1038/s41598-020-65155-1
Yuqiang Yu, Marta Zielinska, Wei Li, Dominic B. Bernkopf, Christiane S. Heilingloh, Markus F. Neurath, Christoph Becker
PGAM5-MAVS interaction regulates TBK1/ IRF3 dependent antiviral responses
FRONTIERS IN IMMUNOLOGY
Volume: 11
Published: May 2020
DOI: 10.3389/fimmu.2020.00691
Anja Schulz-Kuhnt, Vicky Greif, Kai Hildner, Lisa Knipfer, Michael Dobronti, Sabine Zirlik, Florian Fuchs, Raja Atreya, Sebastian Zundler, Rocio Lopez-Posadas, Clemens Neufert, Andreas Ramming, Alexander Kiefer, Anika Gruneboom, Erwin Strasser, Stefan Wirtz, Markus F. Neurath, Imke Atreya
ILC2 Lung-Homing in Cystic Fibrosis Patients: Functional Involvement of CCR6 and Impact on Respiratory Failure
FRONTIERS IN IMMUNOLOGY
Volume: 11
Published: June 2020
DOI: 10.3389/fimmu.2020.01062
Anja Schulz-Kuhnt, Stefan Wirtz, Markus F. Neurath, Imke Atreya
Regulation of Human Innate Lymphoid Cells in the Context of Mucosal Inflammation
JOURNAL OF PATHOLOGY
Volume: 251
Published: June 2020
DOI: 10.1002/path.5437
Nadine Mikuda, Ruth Schmidt-Ullrich, Eva Kergel, Laura Golusda, Jana Wolf, Uta E. Hpken, Claus Scheidereit, Anja A. Kühl, Marina Kolesnischenko
Deficiency in IκBα in the intestinal epithelium leads to spontaneous inflammation and mediates apoptosis in the gut
GASTROENTEROLOGY
Volume: –
Published: June 2020
DOI: 10.1053/j.gastro.2020.05.081
Lucas Kreiß, Oana-Maria Thoma, Ashwathama Dilipkumar, Birgitta Carlé, Pascal Longequeue, Timo Kunert, Timo Rath, Kai Hildner, Clemens Neufert, Michael Vieth, Markus F. Neurath, Oliver Friedrich, Sebastian Schürmann, Maximilian J. Waldner
Label-Free In Vivo Histopathology of Experimental Colitis via 3-Channel Multiphoton Endomicroscopy
ANALYTICAL CHEMISTRY
Volume: –
Published: July 2020
DOI: 10.1021/acs.analchem.0c01902
Juan Pablo Fuenzalida Werner, Yuanhui Huang, Kanuj Mishra, Robert Janowski, Paul Vetschera, Christina Heichler, Andriy Chmyrov, Clemens Neufert, Dierk Niessing, Vasilis Ntziachristos, Andre C. Stiel
Challenging a Preconception: Optoacoustic Spectrum Differs from the Optical Absorption Spectrum of Proteins and Dyes for Molecular Imaging
JOURNAL OF EXPERIMENTAL MEDICINE
Volume: 217
Published: August 2020
DOI: 10.1084/jem.20190133
Marina Babic, Christoforos Dimitropoulos, Quirin Hammer, Christina Stehle, Frederik Heinrich, Assel Sarsenbayeva, Almut Eisele, Pawel Durek, Mir-Farzin Mashreghi, Berislav Lisnic, Jacques Van Snick, Max Lohning, Simon Fillareau, David R. Withers, Nicola, Gagliani, Samuel Huber, Richard A. Flavell, Bojan Polic, Chiara Romagnani
NK cell receptor NKG2D enforces proinflammatory features and pathogenicity of Th1 and Th17 cells
PHARMACOLOGICAL RESEARCH
Volume: 158
Published: August 2020
DOI: 10.1016/j.phrs.2020.104835
EBIOMEDICINE
Volume: 58
Published: August 2020
DOI: 10.1016/j.ebiom.2020.102925
Moritz Leppkes, Jasmin Knopl, Elisabeth Naschberger, Aylin Lindemann, Jeeshan Singh, Irmgard Herrmann, Michael Stürzl, Leonie Staats, Aparna Mahajan, Christine Schauer, Anita N. Kremer, Simon Volkl, Kerstin Amann, Katja Evert, Chrstina Falkies, Andrea Wehrfritz, Ralf J. Rieker, Arndt Hartmann, Andreas E. Kremer, Markus F. Neurath, Luis E. Munoz, Georg Schett, Martin Herrmann
Vascular occlusion by neutrophil extracellular traps in COVID-19
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
Volume: 17
Published: September 2020
DOI: 10.1038/s41575-020-0326-4
Jay V. Patankar, Christoph Becker
Cell death in the gut epithelium and implications for chronic inflammation
BIOINFORMATICS
Volume: 36
Published: September 2020
DOI: 10.1093/bioinformatics/btaa611
Gregor Sturm, Tamas Szabo, Georgios Fotakis, Marlene Haider, Dietmar Rieder, Zlatko Trajanoski, Francesca Finotello
Scirpy: a Scanpy extension for analyzing single-cell T-cell receptor-sequencing data
CANCER IMMUNOLOGY RESEARCH
Volume: 8
Published: October 2020
DOI: 10.1158/2326-6066.CIR-20-0270
Kim E. Kortekaas, Saskia J. Santegoets, Gregor Sturm, Ilina Ehsan, Sylvia L. van Egmond, Francesca Finotello, Zlatko Trajanoski, Marij J. P. Welters, Mariette I. E. van Poelgeest, Sjoerd H. van der Burg
CD39 Identifies the CD4 + Tumor-Specific T-cell Population in Human Cancer
SCIENTIFIC REPORTS
Volume: 10
Published: August 2020
DOI: 10.1038/s41598-020-69570-2
Ingo Ganzleben, Martin Hohmann, Alexander Gruenberg, Jean Gonzales-Menezes, Michael Vieth, Eva Liebing, Claudia Günther, Veronika Thonn, Daniel Bess, Christoph Becker, Michael Schmidt, Markus F. Neurath, Maximilian J. Waldner
Topical application of Chlorin e6-PVP (Ce6-PVP) for improved endoscopic detection of neoplastic lesions in a murine colitis-associated cancer model
2019
VISCERAL MEDICINE
Volume: 35
DOI: 10.1159/000496838
β6-integrin serves as a novel serum tumor marker for colorectal carcinoma
JOURNAL OF LEUKOCYTE BIOLOGY
Volume: 105
DOI: 10.1002/JLB.HI0718-249RR
Aggregated neutrophil extracellular traps prevent inflammation on the neutrophil-rich ocular surface
NATURE IMMUNOLOGY
Volume: 20
DOI: 10.1038/s41590-018-0298-5
Sebastian Zundler, Emily Becker, Marta Spocinska, Monique Slawik, Loreto Parga-Vidal, Regina Stark, Maximilian Wiendl, Raja Atreya, Timo Rath, Moritz Leppkes, Kai Hildner, Rocío López-Posadas, Sören Lukassen, Arif B. Ekici, Clemens Neufert, Imke Atreya, Klaas P. J. M. van Gisbergen, Markus F. Neurath
Hobit- and Blimp-1-driven CD4+ tissue-resident memory T cells control chronic intestinal inflammation
NATURE
Interleukin-22 protects intestinal stem cells against genotoxic stress
FRONTIERS IN IMMUNOLOGY
Volume:10
Published: February 2019
DOI: 10.3389/fphar.2019.00039
STEM CELL RESEARCH
Volume: 35
Published: February 2019
DOI: 10.1016/j.scr.2019.101383
Marco Bardenbacher, Barbara Ruder, Nathalie Britzen-Laurent, Benjamin Schmid, Maximilian Waldner, Elisabeth Naschberger, Michael Scharl, Werner Müller, Claudia Günther, Christoph Becker, Michael Stürzl, Philipp Tripal
Permeability analyses and three dimensional imaging of interferon gamma-induced barrier disintegration in intestinal organoids
SEMINARS IN IMMUNOLOGY
Volume: 41
Published: February 2019
DOI: 10.1016/j.smim.2019.02.001
Imke Atreya, Markus Kindermann, Stefan Wirtz
Innate lymphoid cells in intestinal cancer development
Volume: 0
Volume: 0
BRAIN STIMULATION
Volume: 12
Published: March 2019
DOI: 10.1016/j.brs.2019.03.001.
Lars Neeb, Arian Bayer, Kian-Elias Bayer, Annabelle Farmer, Jochen B. Fiebach, Britta Siegmund, Magdalena Sarah Volz
Transcranial direct current stimulation in inflammatory bowel disease patients modifies resting-state functional connectivity: A RCT
JOURNAL OF CROHN´S AND COLITIS
Volume: 13
Published: April 2019
DOI: 10.1093/ecco-jcc/jjz036
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume: 20
Published: April 2019
DOI: 10.3390/ijms20081887
Barbara Ruder, Raja Atreya, Christoph Becker
Tumour Necrosis Factor Alpha in Intestinal Homeostasis and Gut Related Diseases
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
Volume:
Published: April 2019
DOI: 10.3791/59043
Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
ADVANCED SCIENCE
Volume: 6
Published: April 2019
DOI: 10.1002/advs.201801735
Label-Free Multiphoton Endomicroscopy for Minimally Invasive In Vivo Imaging
INFLAMMATORY BOWEL DISEASE
Volume: 69
Published: April 2019
DOI: 10.1136/gutjnl-2018-316772
Lena Schleier, Maximilian Wiendl, Karin HeidbredeR, Marie-Theres Binder, Raja Atreya, Timo Rath, Emily Becker, Anja Schulz-Kuhnt, Annette Stahl, Lisa Lou Schulze, Karen Ullrich, Simon F Merz, Lea Bornemann, Matthias Gunzer, Alastair J M Watson, Clemens Neufert, Imke Atreya, Markus F Neurath, Sebastian Zundler
Non-classical monocyte homing to the gut via α4β7 integrin mediates macrophage-dependent intestinal wound healing
FRONTIERS IN PHARMACOLOGY
Volume: 10
Published: April 2019
DOI: 10.3389/fphar.2019.00314
Patrizio Scarozza, Heike Schmitt, Giovanni Monteleone, Markus F. Neurath, Raja Atreya
Oligonucleotides—A Novel Promising Therapeutic Option for IBD
GENOME MEDICINE
Volume: 11
Published: May 2019
DOI: 10.1186/s13073-019-0638-6
Francesca Finotello, Clemens Mayer, Christina Plattner, Gerhard Laschober, Dietmar Rieder, Hubert Hackl, Anne Krogsdam, Zuzana Loncova, Wilfried Posch, Doris Wilflingseder, Sieghart Sopper, Marieke Ijsselsteijn, Thomas P. Brouwer, Douglas Johnson, Yaomin Xu, Yu Wang, Melinda E. Sanders, Monica V. Estrada, Paula Ericsson-Gonzalez, Pornpimol Charoentong, Justin Balko, Noel Filipe da Cunha Carvalho de Miranda, Zlatko Trajanoski
Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data.
DIGESTIVE AND LIVER DISEASE
Volume: 51
Published: June 2019
DOI: 10.1016/j.dld.2019.02.020
Claudia Günther, Teresa Brevini, Fotios Sampaziotis, Markus F. Neurath
What gastroenterologists and hepatologists should know about organoids in 2019
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
Volume: 12
Published: June 2019
DOI: 10.1177/1756284819856865
Entcho Klenske , Christian Bojarski, Maximilian Waldner, Timo Rath, Markus F. Neurath, Raja Atreya
Targeting mucosal healing in Crohn’s disease: what the clinician needs to know
NATURE REVIEWS NEPHROLOGY
Volume: 15
Published: June 2019
DOI: 10.1038/s41581-019-0163-2
Christoph Daniel, Moritz Leppkes, Luis E. Muñoz, Gunnar Schley, Georg Schett, Martin Herrmann
Extracellular DNA traps in inflammation, injury and healing
NATURE IMMUNOLOGY
Volume: 20
Published: June 2019
DOI: 10.1038/s41590-019-0415-0
Markus F. Neurath
Targeting immune cell circuits and trafficking in inflammatory bowel disease
INFLAMMATORY BOWEL DISEASE
Volume: 26
Published: July 2019
DOI: 10.1093/ibd/izz142
Environmental Microbial Factors Determine the Pattern of Inflammatory Lesions in a Murine Model of Crohn’s Disease – Like Inflammation
GENOME MEDICINE
Volume: 11
Published: July 2019
DOI: 10.1186/s13073-019-0662-6
Noel F. C. C. de Miranda, Zlatko Trajanoski
Advancing cancer immunotherapy: a vision for the field
IMMUNITY
Volume: 51
Published: September 2019
DOI: 10.1016/j.immuni.2019.07.002
Luis E. Muñoz, Sebastian Boeltz, Rostyslav Bilyy, Christine Schauer, Aparna Mahajan, Navena Widulin, Anika Grüneboom, Irmgard Herrmann, Edgyda Boada, Manfred Rauh, Veit Krenn, Mona H. C. Biermann, Malgorzata J. Podolska, Jonas Hahn, Jasmin Knopf, Christian Maueröder, Solomiya Paryzhak, Tetiana Dumych, Yi Zhao, Markus F. Neurath, Markus H. Hoffmann, Tobias A. Fuchs, Moritz Leppkes, Georg Schett, Martin Herrmann
Neutrophil Extracellular Traps Initiate Gallstone Formation
GUT
Volume: 68
Published: September 2019
DOI: 10.1136/gutjnl-2018-317977
Sebastian Zundler, Emily Becker, Lisa Lou Schulze, Markus F Neurath
Immune cell trafficking and retention in inflammatory bowel disease: mechanistic insights and therapeutic advances
JOURNAL OF LEUKOCYTE BIOLOGY
Volume: 106
Published: September 2019
DOI: 10.1002/JLB.3AB0918-370R
Malgorzata J. Podolska, Aparna Mahajan, Jonas Hahn, Jasmin Knopf, Christian Maueröder, Lenka Petru, Marc Ullmann, Georg Schett, Moritz Leppkes, Martin Herrmann, Luis E. Muñoz, Christine Schauer
Treatment with DNases rescues hidden neutrophil elastase from aggregated NETs
MEDICINE
Volume: 98
Published: September 2019
DOI: 10.1097/MD.0000000000017017
Kian-Elias Bayer, Lars Neeb, Arian Bayer, Jakob Johann Wiese, Britta Siegmund, Magdalena Sarah Prüß
Reduction of intra-abdominal pain through transcranial direct current stimulation: A systematic review
FRONTIERS IN IMMUNOLOGY
Volume: 10
Published: September 2019
DOI: 10.3389/fimmu.2019.02176
Jasmin Knopf, Moritz Leppkes, Georg Schett, Martin Herrmann, Luis E. Munoz
Aggregated NETs Sequester and Detoxify Extracellular Histones
NATURE REVIEWS GENETICS
Volume: 20
Published: September 2019
DOI: 10.1038/s41576-019-0166-7
Francesca Finotello, Dietmar Rieder, Hubert Hackl, Zlatko Trajanoski
Next-generation computational tools for interrogating cancer immunity
SEMINARS IN IMMUNPATHOLOGY
Volume: 41
Published: September 2019
DOI: 10.1007/s00281-019-00756-1
Heike Schmitt, Clemens Neufert, Markus F. Neurath, Raja Atreya
Resolution of Crohn´s disease
AMERICAN JOURNAL OF PHYSIOLOGY – GASTROINTESTINAL AND LIVER
Volume: 317
Published: October 2019
DOI: 10.1152/ajpgi.00297.2018
Deletion of the Casp8 gene in mice results in ileocolitis, gut barrier dysfunction, and malassimilation, which can be partially attenuated by inulin or sodium butyrate
JOURNAL OF CROHN´S AND COLITIS
Volume:
Published: October 2019
DOI: 10.1093/ecco-jcc/jjz170
The TLR9 agonist cobitolimod induces IL10 producing wound healing macrophages and regulatory T cells in ulcerative colitis
FRONTIERS IN IMMUNOLOGY
Volume:10
Published: October 2019
DOI: 10.3389/fimmu.2019.02481
Stefanie Gößwein, Aylin Lindemann, Aparna Mahajan, Christian Maueröder, Eva Martini, Jay Patankar, Georg Schett, Christoph Becker, Stefan Wirtz, Nora Naumann-Bartsch, Marco E. Bianchi, Peter A. Greer, Günter Lochnit, Martin Herrmann, Markus F. Neurath, Moritz Leppkes
Citrullination Licenses Calpain to Decondense Nuclei in Neutrophil Extracellular Trap Formation
JOURNAL OF CLINICAL INVESTIGATION
Volume: 129
Published: November 2019
DOI: 10.1172/JCI124884
Victoria Langer, Eugenia Vivi, Daniela Regensburger, Thomas H. Winkler, Maximilian J. Waldner, Timo Rath, Benjamin Schmid, Lisa Skottke, Somin Lee, Noo Li Jeon, Thomas Wohlfahrt, Viktoria Kramer, Philipp Tripal, Michael Schumann, Stephan Kersting, Claudia Handtrack, Carol I. Geppert, Karina Suchowski, Ralf H. Adams, Christoph Becker, Andreas Ramming, Elisabeth Naschberger, Nathalie Britzen-Laurent, Michael Stürzl
IFN-γ drives inflammatory bowel disease pathogenesis through VE-cadherin–directed vascular barrier disruption
GASTROENTEROLOGY
Volume: 157
Published: November 2019
DOI: 10.1053/j.gastro.2019.07.007
Rocío López-Posadas, PetraFastancz, Luz del Carmen Martínez-Sánchez, Julia Panteleev-Ivlev, Veronika Thonn, Tatyana Kisseleva, Lukas S. Becker, Anja Schulz-Kuhnt, Sebastian Zundler, Stefan Wirtz, Raja Atreya, Birgitta Carlé, Oliver Friedrich, Sebastian Schürmann, Maximilian J. Waldner, Clemens Neufert, Cord H. Brakebusch, Martin O. Bergö, Markus F. Neurath, Imke Atreya
Inhibiting PGGT1B Disrupts Function of RHOA, Resulting in T-cell Expression of Integrin α4β7 and Development of Colitis in Mice
GASTROENTEROLOGY
Volume: 157
Published: November 2019
DOI: 10.1053/j.gastro.2019.07.031
Claudia Günther, Barbara Ruder, Iris Stolzer, Heidrun Dorner, Gui-Wei He, Mircea Teodor Chiriac, Konrad Aden, Anne Strigli, Miriam Bittel, Sebastian Zeissig, Philip Rosenstiel, Raja Atreya, Markus F. Neurath, Stefan Wirtz, Christoph Becker
Interferon Lambda Promotes Paneth Cell Death Via STAT1 Signaling in Mice and Is Increased in Inflamed Ileal Tissues of Patients With Crohn’s Disease
NATURE COMMUNICATIONS
Volume: 10
Published: November 2019
DOI: 10.1038/s41467-019-13559-7
Jörn F. Ziegler, Chotima Böttcher, Marilena Letizia, Cansu Yerinde, Hao Wu, Inka Freise, Yasmina Rodriguez-Sillke, Ani K. Stoyanova, Martin E. Kreis, Patrick Asbach, Desiree Kunkel, Josef Priller, Ioannis Anagnostopoulos, Anja A. Kühl, Konstanze Miehle, Michael Stumvoll, Florian Tran, Broder Fredrich, Michael Forster, Andre Franke, Christian Bojarski, Rainer Glauben, Britt-Sabina Löscher, Britta Siegmund, Carl Weidinger
Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn’s disease
IMMUNITY
Volume: 51
Published: November 2019
DOI: 10.1016/j.immuni.2019.10.011
CELL DEATH & DISEASE
Volume: 10
Published: November 2019
DOI: 10.1038/s41419-019-2115-y
Miriam Bittel, Andreas E. Kremer, Michael Stürzl, Stefan Wirtz, Iris Stolzer, Markus F. Neurath, Gianna Ballon, Claudia Günther
Modulation of the extrinsic cell death signaling pathway by viral Flip induces acute-death mediated liver failure
FRONTIERS IN IMMUNOLOGY
Volume: 10
Published: November 2019
DOI: 10.3389/fimmu.2019.02718
Cansu Yerinde, Britta Siegmund, Rainer Glauben, Carl Weidinger
Metabolic Control of Epigenetics and Its Role in CD8+ T Cell Differentiation and Function
EXPERT OPINION ON BIOLOGICAL THERPY
Volume: 20
Published: November 2019
DOI: 10.1080/14712598.2020.1695775
Clemens Neufert, Markus F. Neurath, Raja Atreya
Rationale for IL-36 receptor antibodies in ulcerative colitis
CURRENT OPINION IN GASTROENTEROLOGY
Volume: 35
Published: November 2019
DOI:10.1097/MOG.0000000000000579
Sebastian Zundler, Maximilian Wiendl, Markus F. Neurath
Anti-trafficking agents in the treatment of inflammatory bowel disease
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume: 20
Published: November 2019
DOI: 10.3390/ijms20225597
Deborah Delbue, Danielle Cardoso-Silva, Federica Branchi, Alice Itzlinger, Marilena Letizia, Britta Siegmund, Michael Schumann
Celiac Disease Monocytes Induce a Barrier Defect in Intestinal Epithelial Cells
SEMINARS IN IMMUNOPATHOLOGY
Volume: 41
Published: November 2019
DOI: 10.1007/s00281-019-00771-2
SENSORS AND ACTUATORS
Volume: 301
Published: December 2019
DOI: 10.1016/j.snb.2019.127121
Lucas Kreiß, Martin Hohmann, Florian Klämpfl, Sebastian Schürmann, Faramarz Dehghani, Michael Schmidt, Oliver Friedrich, Lorenz Büchler
Diffuse reflectance spectroscopy and Raman spectroscopy for label-free molecular characterization and automated detection of human cartilage and subchondral bone
SCIENTIFIC REPORTS
Volume: 9
Published: December 2019
DOI: 10.1038/s41598-019-55852-x
Chotima Böttcher, Camila Fernández-Zapata, Stephan Schlickeiser, Desiree Kunkel, Axel R. Schulz, Henrik E. Mei, Carl Weidinger, René M. Gieß, Susanna Asseyer, Britta Siegmund, Friedemann Paul, Klemens Ruprecht, Josef Priller
Multi-parameter immune profiling of peripheral blood mononuclear cells by multiplexed single-cell mass cytometry in patients with early multiple sclerosis
SEMINARS IN ARTHRITIS AND RHEUMATISM
Volume: 49
Published: December 2019
DOI: 10.1016/j.semarthrit.2019.09.011
Moritz Leppkes, Maximilian Schick, Bettina Hohberger, Aparna Mahajan, Jasmin Knopf, Georg Schett, Luis E. Munoz, Martin Herrmann
Updates on NET formation in health and disease
NATURE MEDICINE
Volume: 25
Published: December 2019
DOI: 10.1038/s41591-019-0669-y
Adrian P. Regensburger, Lina M. Fonteyne, Jörg Jüngert, Alexandra L. Wagner, Teresa Gerhalter, Armin M. Nagel, Rafael Heiss, Florian Flenkenthaler, Matthias Qurashi, Markus F. Neurath, Nikolai Klymiuk, Elisabeth Kemter, Thomas Fröhlich, Michael Uder, Joachim Woelfle, Wolfgang Rascher, Regina Trollmann, Eckhard Wolf, Maximilian J. Waldner, Ferdinand Knieling
Detection of collagens by multispectral optoacoustic tomography as an imaging biomarker for Duchenne muscular dystrophy
2018
Volume: 9
Volume: 9
Volume: 19
Published: August 2018
Quirin Hammer, Timo Rückert & Chiara Romagnani
Volume: 475
Published: August 2018
Volume: 11
Published: August 2018
DOI: 10.1038/s41385-018-0068-6
JOURNAL OF CROHN´S AND COLITIS
Volume: 13
Published: October 2018
DOI: 10.1093/ecco-jcc/jjy146
T-cell Composition in Ileal and Colonic Creeping Fat – Separating Ileal from Colonic Crohn’s Disease
Volume: 9
Volume: 3
Volume: 286
MUCOSAL IMMUNOLOGY
Volume: 12
DOI: 10.1038/s41385-018-0107-3
Christoph Schubart, Branislav Krljanac, Manuel Otte, Cornelia Symowski, Eva Martini, Claudia Günther, Christoph Becker, Christoph Daniel, David Voehringer
Selective expression of constitutively activated STAT6 in intestinal epithelial cells promotes differentiation of secretory cells and protection against helminths
Volume: 0
Volume: 113
Volume: 142
Volume: 8
Volume: 22
2021
Lang-Schwarz C, Agaimy A, Atreya R, Becker C, Danese S, Fléjou JF, Gaßler N, Grabsch HI, Hartmann A, Kamarádová K, Kühl AA, Lauwers GY, Lugli A, Nagtegaal I, Neurath MF, Oberhuber G, Peyrin Biroulet L, Rath T, Riddell R, Rubio CA, Sheahan K, Tilg H, Villanacci V, Westerhoff M, Vieth M.
Maximizing the diagnostic information from biopsies in chronic inflammatory bowel diseases: recommendations from the Erlangen International Consensus Conference on Inflammatory Bowel Diseases and presentation of the IBD-DCA score as a proposal for a new index for histologic activity assessment in ulcerative colitis and Crohn’s disease.
Virchows Arch. 2021 Mar;478(3):581-594.
doi: 10.1007/s00428-020-02982-7. Epub 2020 Dec 29. PMID: 33373023; PMCID: PMC7973393.
Patankar JV, Chiriac MT, Lehmann M, Kühl AA, Atreya R, Becker C, Gonzalez-Acera M, Schmitt H, Gamez-Belmonte R, Mahapatro M, Diemand L, Hartmann L, Mascia F, Hracsko Z, Thonn V, Schödel L, Zielinska M, Yu Y, Erkert L, Li W, Zeitler M, Ruder B, Ganzleben I, Günther C, Voehringer D, Zundler S, Neurath MF, Siegmund B
Severe Acute Respiratory Syndrome Coronavirus 2 Attachment Receptor Angiotensin-Converting Enzyme 2 Is Decreased in Crohn’s Disease and Regulated By Microbial and Inflammatory Signaling.
Gastroenterology. 2021 Feb;160(3):925-928.e4.
doi: 10.1053/j.gastro.2020.10.021. Epub 2020 Oct 17. PMID: 33075345; PMCID: PMC7567698.
Enderle K, Dinkel M, Spath EM, Schmid B, Zundler S, Tripal P, Neurath MF, Hildner K, Neufert C.
Dynamic Imaging of IEL-IEC Co-Cultures Allows for Quantification of CD103 Dependent T Cell Migration.
Int J Mol Sci. 2021 May 13;22(10):5148.
doi: 10.3390/ijms22105148. PMID: 34067987; PMCID: PMC8152227.
Ackermann M, Anders HJ, Bilyy R, Bowlin GL, Daniel C, De Lorenzo R, Egeblad M, Henneck T, Hidalgo A, Hoffmann M, Hohberger B, Kanthi Y, Kaplan MJ, Knight JS, Knopf J, Kolaczkowska E, Kubes P, Leppkes M, Mahajan A, Manfredi AA, Maueröder C, Maugeri N, Mitroulis I, Muñoz LE, Narasaraju T, Naschberger E, Neeli I, Ng LG, Radic MZ, Ritis K, Rovere-Querini P, Schapher M, Schauer C, Simon HU, Singh J, Skendros P, Stark K, Stürzl M, van der Vlag J, Vandenabeele P, Vitkov L, von Köckritz-Blickwede M, Yanginlar C, Yousefi S, Zarbock A, Schett G, Herrmann M
Patients with COVID-19: in the dark-NETs of neutrophils.
Cell Death Differ. 2021 May 24:1–15.
doi: 10.1038/s41418-021-00805-z. Epub ahead of print. PMID: 34031543; PMCID: PMC8142290.
Buchbender M, Fehlhofer J, Proff P, Möst T, Ries J, Hannig M, Neurath MF, Gund M, Atreya R, Kesting M.
Expression of inflammatory mediators in biofilm samples and clinical association in inflammatory bowel disease patients-a preliminary study.
Clin Oral Investig. 2021 Aug 12.
doi: 10.1007/s00784-021-04093-2. Epub ahead of print. PMID: 34383142.
Günther C, Rothhammer V, Karow M, Neurath M, Winner B.
The Gut-Brain Axis in Inflammatory Bowel Disease Current and Future Perspectives.
Int J Mol Sci. 2021 Aug 18;22(16):8870.
doi: 10.3390/ijms22168870. PMID: 34445575; PMCID: PMC8396333.
Gonzalez Acera M, Bubeck M, Mascia F, Diemand L, Sturm G, Kühl AA, Atreya R, Lie DC, Neurath MF, Schumann M, Klose CSN, Trajanoski Z, Becker C, Patankar JV.
Dynamic, Transient, and Robust Increase in the Innervation of the Inflamed Mucosa in Inflammatory Bowel Diseases.
Cells. 2021 Aug 30;10(9):2253.
doi: 10.3390/cells10092253. PMID: 34571902; PMCID: PMC8471820.
Haghikia A, Zimmermann F, Schumann P, Jasina A, Roessler J, Schmidt D, Heinze P, Kaisler J, Nageswaran V, Aigner A, Ceglarek U, Cineus R, Hegazy AN, van der Vorst EPC, Döring Y, Strauch CM, Nemet I, Tremaroli V, Dwibedi C, Kränkel N, Leistner DM, Heimesaat MM, Bereswill S, Rauch G, Seeland U, Soehnlein O, Müller DN, Gold R, Bäckhed F, Hazen SL, Haghikia A, Landmesser U.
Propionate attenuates atherosclerosis by immune-dependent regulation of intestinal cholesterol metabolism.
Eur Heart J. 2021 Oct 1:ehab644.
doi: 10.1093/eurheartj/ehab644. Epub ahead of print. PMID: 34597388.
Bittel M, Reichert P, Sarfati I, Dressel A, Leikam S, Uderhardt S, Stolzer I, Phu TA, Ng M, Vu NK, Tenzer S, Distler U, Wirtz S, Rothhammer V, Neurath MF, Raffai RL, Günther C, Momma S.
Visualizing transfer of microbial biomolecules by outer membrane vesicles in microbe-host-communication in vivo.
J Extracell Vesicles. 2021 Oct;10(12):e12159. doi: 10.1002/jev2.12159. PMID: 34664784.
Lang-Schwarz C, Angeloni M, Agaimy A, Atreya R, Becker C, Dregelies T, Danese S, Fléjou JF, Gaßler N, Grabsch HI, Hartmann A, Kamarádová K, Kühl AA, Lauwers GY, Lugli A, Nagtegaal I, Neurath MF, Oberhuber G, Peyrin-Biroulet L, Rath T, Riddell R, Rubio CA, Sheahan K, Siegmund B, Tilg H, Villanacci V, Westerhoff M, Ferrazzi F, Vieth M.
Validation of the ‚Inflammatory Bowel Disease-Distribution, Chronicity, Activity [IBD-DCA] Score‘ for Ulcerative Colitis and Crohn´s Disease.
J Crohns Colitis. 2021 Oct 7;15(10):1621-1630.
doi: 10.1093/ecco- jcc/jjab055. PMID: 33773497; PMCID: PMC8495487.
Lehmann M, Allers K, Heldt C, Meinhardt J, Schmidt F, Rodriguez-Sillke Y, Kunkel D, Schumann M, Böttcher C, Stahl-Hennig C, Elezkurtaj S, Bojarski C, Radbruch H, Corman VM, Schneider T, Loddenkemper C, Moos V, Weidinger C, Kühl AA, Siegmund B
Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8 T cells.
Mucosal Immunol. 2021 Nov;14(6):1381-1392.
doi: 10.1038/s41385-021-00437-z. Epub 2021 Aug 21. PMID: 34420043; PMCID: PMC8379580.
2020
Carbotti G, Petretto A, Naschberger E, Stürzl M, Martini S, Mingari MC, Filaci G, Ferrini S, Fabbi M
Cytokine-Induced Guanylate Binding Protein 1 (GBP1) Release from Human Ovarian Cancer Cells.
Cancers (Basel). 2020 Feb 19;12(2):488.
doi: 10.3390/cancers12020488. PMID: 32093058; PMCID: PMC7072386.
Breidert M, Eftekhari P, Louis F, Rotoiu C, Rath T, Neurath MF, Atreya R
Functional Molecular Network Analysis Enables Prediction of Response to Vedolizumab Therapy in Anti-TNF Refractory IBD Patients.
Crohns Colitis 360. 2020 Apr;2(2):otaa037.
doi: 10.1093/crocol/otaa037. Epub 2020 May 24. PMID: 32776006; PMCID: PMC7397736.
Beller A, Kruglov A, Durek P, von Goetze V, Werner K, Heinz GA, Ninnemann J, Lehmann K, Maier R, Hoffmann U, Riedel R, Heiking K, Zimmermann J, Siegmund B, Mashreghi MF, Radbruch A, Chang HD
Specific microbiota enhances intestinal IgA levels by inducing TGF-β in T follicular helper cells of Peyer’s patches in mice.
Eur J Immunol. 2020 Jun;50(6):783-794.
doi: 10.1002/eji.201948474. Epub 2020 Feb 27. PMID: 32065660.
Atreya R, Neurath MF, Siegmund B
Personalizing Treatment in IBD: Hype or Reality in 2020? Can We Predict Response to Anti-TNF?
Front Med (Lausanne). 2020 Sep 2;7:517.
doi: 10.3389/fmed.2020.00517. PMID: 32984386; PMCID: PMC7492550.
Gamez-Belmonte R, Erkert L, Wirtz S, Becker C
The Regulation of Intestinal Inflammation and Cancer Development by Type 2 Immune Responses.
Int J Mol Sci. 2020 Dec 21;21(24):9772.
doi: 10.3390/ijms21249772. PMID: 33371444; PMCID: PMC7767427.
2019
Zundler S, Becker E, Spocinska M, Slawik M, Parga-Vidal L, Stark R, Wiendl M, Atreya R, Rath T, Leppkes M, Hildner K, López Posadas R, Lukassen S, Ekici AB, Neufert C, Atreya I, van Gisbergen KPJM, Neurath MF.
Hobit- and Blimp-1-driven CD4+ tissue-resident memory T cells control chronic intestinal inflammation.
Nat Immunol. 2019 Apr;20(4):514. doi: 10.1038/s41590-019-0360-y. Erratum for: Nat Immunol. 2019 Mar;20(3):288-300.
PMID: 30846879.
Ruder B, Atreya R, Becker C
Tumour Necrosis Factor Alpha in Intestinal Homeostasis and Gut Related Diseases.
Int J Mol Sci. 2019 Apr 16;20(8):1887.
doi: 10.3390/ijms20081887. PMID: 30995806; PMCID: PMC6515381.
Delbue D, Cardoso-Silva D, Branchi F, Itzlinger A, Letizia M, Siegmund B, Schumann M
Celiac Disease Monocytes Induce a Barrier Defect in Intestinal Epithelial Cells.
Int J Mol Sci. 2019 Nov 9;20(22):5597. doi:
10.3390/ijms20225597. PMID: 31717494; PMCID: PMC6888450.
2018
Itzlinger A, Branchi F, Elli L, Schumann M.
Gluten-Free Diet in Celiac Disease-Forever and for All?
NUTRIENTS. 2018 Nov 18;10(11):1796.
doi: 10.3390/nu10111796. PMID: 30453686; PMCID: PMC6267495.