Research Projects

Project Area A

Immune Regulation of Intestinal Barrier Functions

Prof. Dr. Andreas Diefenbach
© Jacqueline Hirscher
Dr. Antigoni Triantafyllopoulou
© Jacqueline Hirscher

A01

Innate modules of intestinal epithelial cell protection in inflammatory bowel diseases

Prof. Dr. Andreas Diefenbach & Dr. Antigoni Triantafyllopoulou

PD Dr. Claudia Günther
© Universitätsklinikum Erlangen

A02

Mechanisms linking IFN-mediated mixed lineage kinase domain-like protein activation with intestinal inflammation

PD Dr. Claudia Günther

© Universitätsklinikum Erlangen
© Universitätsklinikum Erlangen
© Universitätsklinikum Erlangen
© Universitätsklinikum Erlangen

A03

Mucosal type 2 immunity as regulator of epithelial cell functions in inflammatory bowel diseases

Prof. Dr. Christoph Becker & PD Dr. Stefan Wirtz

© Jacqueline Hirscher
© Jacqueline Hirscher

A04

Microbiota - TLR4 - TNFα axis in control of epithelial tissue functions in IBD

Dr. Andrey Kruglov

© Fotograf
© Fotograf

A05

Oncostatin M - a novel cytokine in inflammatory bowel diseases pathogenesis

Prof. Dr. Ahmed N. Hegazy

© Universitätsklinikum Erlangen
© Universitätsklinikum Erlangen
© Universitätsklinikum Erlangen
© Universitätsklinikum Erlangen

A06

Inflammation-induced intestinal vascular barrier dysfunctions and their impact on the immune-epithelial crosstalk in inflammatory bowel diseases

Prof. Dr. Michael Stürzl & PD Dr. Natalie Britzen-Laurent

© Universitätsklinikum Erlangen
© Universitätsklinikum Erlangen
© Universitätsklinikum Erlangen
© Universitätsklinikum Erlangen

A07

Regulation and function of prenylation within intestinal epithelial cells in the context of inflammation

Dr. Imke Atreya & Dr. Rocío López-Posadas

© Universitätsklinikum Erlangen
© Universitätsklinikum Erlangen
© Universitätsklinikum Erlangen
© Universitätsklinikum Erlangen

A08

Molecular and functional studies on the crosstalk between induced IELs and IECs in intestinal homeostasis and inflammation

Prof. Dr. Kai Hildner & PD Dr. Clemens Neufert

Project Area B

Epithelium as Modifier of Mucosal Immunity and Inflammation

© Charite Berlin
© Charite Berlin

B01

Mesenteric fat - an immunological barrier in Crohn's disease

Dr. Carl Weidinger & Prof. Dr. Britta Siegmund

© DRFZ Berlin
© DRFZ Berlin

B02

Signals mediating crosstalk of intestinal epithelial cells with innate lymphoid cells in inflammatory bowel diseases

Prof. Dr. Chiara Romagnani

© Jacqueline Hirscher
© Jacqueline Hirscher
© Gero Breloer
© Gero Breloer

B03

The intestinal epithelial cells in the dialogue between microbiota and the immune system

Dr. Hyun-Dong Chang & Prof. Dr. Andreas Radbruch

© Universitätsklinikum Erlangen
© Universitätsklinikum Erlangen

B04

The emergency barrier function of neutrophil extracellular traps and their interaction with the intestinal epithelium

Prof. Dr. Martin Herrmann & Dr. Moritz Leppkes

© Franziska Männel/ Universitäts-Klinikum Erlangen-Nürnberg
© Franziska Männel/ Universitäts-Klinikum Erlangen-Nürnberg

B05

Neuropeptides and TRP channels as effectors in colonic epithelial and immune cell function in IBD

PD Dr. Matthias Engel

© Charite Berlin
© Charite Berlin

B06

Interplay of the impaired tight junction and the subjacent immune cells in IBD

PD Dr. Susanne M. Krug & Prof. Dr. Jörg-Dieter Schulzke

© Jürgen Haacks/Universität Kiel
© Jürgen Haacks/Universität Kiel

B07

Identification and functional characterization of human microbiota-specific regulatory T cells

Prof. Dr. Alexander Scheffold

Project Area C

Diagnostics and Therapeutic Intervention

© Universitätsklinikum Erlangen
© Universitätsklinikum Erlangen

C01

Determining function and dysfunction of the intestinal epithelium using advanced label-free imaging techniques

Prof. Dr. Maximilian Waldner & Dr. Sebastian Schürmann

© Universitätsklinikum Erlangen
© Universitätsklinikum Erlangen
© Charite Berlin
© Charite Berlin

C02

In vivo endoscopic molecular imaging to predict response to biological therapies in ulcerative colitis

Prof. Dr. Raja Atreya & PD Dr. Christan Bojarski

© Universitätsklinikum Erlangen
© Universitätsklinikum Erlangen
© Charite Berlin
© Charite Berlin

C03

Transcranial direct current stimulation for chronic, IBD-associated abdominal pain and the relation of pain perception and the intestinal epithelial barrier

Dr. Magdalena Prüß & Dr. Michael Schumann & Prof. Dr. Raja Atreya

© Peter Pulkowski
© Peter Pulkowski

C04

A phase II multi-center clinical trial to study efficacy and in vivo trafficking of autologous adoptively transferred ex vivo expanded regulatory T cells in patients with ulcerative colitis

Dr. Caroline Bosch-Voskens & Prof. Dr. Markus F. Neurath

Project Area Z

(Administration and Management)
© Universitätsklinikum Erlangen
© Universitätsklinikum Erlangen
© Charite Berlin
© Charite Berlin

IBDome

Prof. Dr. Raja Atreya & Prof. Dr. Zlatko Trajanoski & PD Dr. Anja A. Kühl

© Universitätsklinikum Erlangen
© Universitätsklinikum Erlangen
© DRFZ Berlin
© DRFZ Berlin

Integrated Research Training Group

Dr. Imke Atreya & Prof. Dr. Chiara Romagnani

© Universitätsklinikum Erlangen
© Universitätsklinikum Erlangen
© Charite Berlin
© Charite Berlin

Project Management and Administration

Prof. Dr. Christoph Becker & Prof. Dr. Britta Siegmund